September 1969 saw the dawn of an era when Warren Publishing launched a new title to supplement their ongoing series of Horror magazines. Eerie and Creepy were the flagship titles, with a motley selection of horror stories in each issue. As a counterpoint to the male, ghoulish presenters of Eerie and Creepy, it was decided that the new title should be fronted by a female - and a pretty one at that!
Forrest J. Ackerman and James Warren (reputedly inspired by the film Barbarella) came up with the idea of a "vampire-ella". A rising star in the art world was asked to create the front cover illustration, and the now legendary Frank Frazetta provided the world with their first glimpse of Vampirella.
Reputedly the first ever drawing of Vampirella (Frank Frazetta - 1969)
* May I recommend Mike Grace's excellent Vampirella-Revealed web site if you want to read the story of Vampirella in a sequential timeline.